Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Tamoxifen inhibits astrocytic JAK2/STAT3 pathway in rats with traumatic spinal injury

Jun Wang , Ke Su, Long-Jie Li, Shi-Yun Ma

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Research Centre, Mazandaran University of Medical Sciences, Sari, Iran;

For correspondence:- Jun Wang Email: wangjun15181@gmail.com Tel:+863172075651

Received: 3 May 2016 Accepted: 15 May 2017 Published: 29 June 2017

Citation: Wang J, Su K, Li L, Ma S. Tamoxifen inhibits astrocytic JAK2/STAT3 pathway in rats with traumatic spinal injury. Trop J Pharm Res 2017; 16(6):1277-1283 doi: 10.4314/tjpr.v16i6.10

© 2017 The authors.
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Abstract

Purpose: To investigate the reducing effect of Morinda citrifolia capsules (MCC) on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemia patients.

Methods: This study was a randomized double-blind placebo-controlled clinical trial, with 60 subjects placed in two groups, viz, experimental (MCC group) and placebo (P group). The first group received two capsules of MCC (each capsule contains 500 mg extract) while the second group received two capsules of placebo (comprised of 500 mg fillers) 3 times daily, for 14 days for both groups. Overnight fasting cubiti venous blood (3 mL) was taken from each subject each time measurements were carried out. TC and LDL-C were measured by spectrophotometric assay using an automated analyzer.

Results: The results show that there was significant decrease in TC and LDL-C on day 14, compared to control (P group). Reduction in TC and LDL-C was 13.8 and 15.5 %, respectively. Decrease in TC and LDL-C levels was influenced by factors, such as age, BMI, exercise, diet, and smoking habits. In MCC group, the capsules significantly decreased TC levels (p < 0.05).

Conclusion: The results suggest that 1 g MCC, given orally thrice daily, significantly reduces TC and LDL-C levels in patients with hypercholesterolemia.

Keywords: Hypercholesterolemia, Cholesterol levels, Morinda citrifolia